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Butyrylcholinesterase activity and risk factors for coronary artery disease
V M Alcântara1, E A Chautard-Freire-Maia, M Scartezini
1vma@ufpr.br
Insights
This study found that apolipoprotein B, triglycerides, and diabetes mellitus are independently linked to butyrylcholinesterase activity in individuals at risk for coronary artery disease.
Area of Science:
- Biochemistry and Cardiovascular Health
- Biomarker Discovery for Disease Risk
Background:
- Coronary artery disease (CAD) risk factors are multifactorial.
- Butyrylcholinesterase (BChE) activity has been implicated in various metabolic processes.
- Understanding BChE's role in CAD pathogenesis is crucial for risk stratification.
Purpose of the Study:
- To identify specific coronary artery disease risk factors independently correlated with butyrylcholinesterase (BChE) activity.
- To elucidate the relationship between BChE activity and key metabolic and clinical parameters.
Main Methods:
- Study involved 88 White individuals with varying cardiovascular risk factors.
- Correlation analysis assessed relationships between BChE activity and various parameters.
- Step-wise multiple regression identified independent predictors of BChE activity.
Main Results:
- Simple correlation showed BChE activity linked to age, sex, BMI, hypertension, diabetes mellitus (DM), triglycerides (TGs), total cholesterol, LDL cholesterol, and apolipoprotein B (Apo B).
- Multiple regression analysis revealed independent correlations of BChE activity with Apo B, TGs, and DM.
Conclusions:
- Apolipoprotein B, triglycerides, and diabetes mellitus are independently associated with butyrylcholinesterase activity.
- Findings support BChE's role in lipoprotein metabolism and potential links to diabetes mellitus and hypertension.
Abstract:
The aim of this study was to verify which risk factors for coronary artery disease (CAD) are independently correlated with butyrylcholinesterase (BChE) activity. We studied 88 White individuals (43 males) aged 47.3+/-15.7 years (mean+/-SD; range: 14.0-80.0 years) including 38 with hyperlipidemia, 30 with hypertension and 5 with diabetes mellitus (DM). Simple correlation analysis showed that BChE activity was positively correlated with age, sex, body mass index, hypertension and DM, as well as with triglycerides (TGs), total cholesterol, low-density lipoprotein cholesterol and apolipoprotein B (Apo B). However, after a step-wise multiple regression analysis, the only risk factors for CAD that showed independent correlations with BChE activity were, in descending order of importance, Apo B, TGs and DM. Our findings seem to reinforce suggested associations of BChE activity with lipoprotein synthesis and with hypertension, as well as supporting previous data on the relation of BChE activity with disturbances found in diabetes mellitus.