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Related Experiment Videos

Antipsychotics: impact on prolactin levels.

Paul J Goodnick1, Lucero Rodriguez, Orlando Santana

  • 1Department of Psychiatry & Behavioural Sciences, University of Miami School of Medicine, 1400 NW 10 Avenue, Ste 304A, Miami, FL 33136, USA. pgoodnick@aol.com

Expert Opinion on Pharmacotherapy
|October 22, 2002
PubMed
Summary
This summary is machine-generated.

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Antipsychotic medications can significantly increase human prolactin (hPrl) levels, leading to side effects. However, newer atypical antipsychotics like clozapine and aripiprazole show promise in managing psychosis without elevating hPrl.

Area of Science:

  • Neuroendocrinology
  • Psychopharmacology

Background:

  • Hyperprolactinaemia, a condition of elevated human prolactin (hPrl), is linked to various adverse effects.
  • Antipsychotics, particularly older typical agents, have been extensively studied for their impact on hPrl levels since the 1970s.

Purpose of the Study:

  • To review the effects of different antipsychotic classes on human prolactin (hPrl) levels.
  • To differentiate the prolactin-elevating potential of typical versus atypical antipsychotics.

Main Methods:

  • Literature review of studies investigating antipsychotic-induced hyperprolactinaemia.
  • Analysis of findings from acute and long-term studies involving various antipsychotic medications.

Main Results:

  • Typical antipsychotics (phenothiazines, haloperidol) consistently increase hPrl levels, sometimes significantly and persistently.

Related Experiment Videos

  • Atypical antipsychotics show varied effects: clozapine and aripiprazole can reduce hPrl, while risperidone elevates it, and olanzapine, quetiapine, and ziprasidone have minimal impact.

    • Conclusions:

    • Antipsychotic-induced hyperprolactinaemia is a known side effect, primarily associated with typical agents.
    • Atypical antipsychotics offer a more favorable profile regarding hPrl regulation, with some agents demonstrating a capacity to lower hPrl levels.