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Epidemiology of invasive streptococcus pneumoniae infections in children in Spain, 1996-1998

J Díez-Domingo1, I Pereiró, A Morant

  • 1Vaccine Institute of Valencia, Research Unit Trinitat, Valencia, Spain. diez_jav@gva.es

The Journal of Infection
|October 22, 2002
PubMed
Abstract

Insights

Invasive pneumococcal disease, a major threat to infants, peaked in children under two. Serotypes 19, 14, and 6 were the primary culprits in Valencia, Spain.

Area of Science:

  • Pediatric infectious diseases
  • Bacteriology
  • Epidemiology

Background:

  • Streptococcus pneumoniae causes severe infant meningitis and septicemia with high mortality.
  • Invasive pneumococcal disease (IPD) poses significant risks to young children.

Observation:

  • A three-year surveillance (1996-1998) in Valencia, Spain, monitored invasive bacterial diseases in children up to 15 years old.
  • The study identified 94 cases of IPD in children under 15.

Findings:

  • The annual incidence of IPD was 4.6 per 100,000 children.
  • Children under two years old had the highest incidence rates for invasive disease (16.8/100,000) and meningitis (3.8/100,000).
  • Serotypes 19, 14, and 6 were responsible for 83% of invasive pneumococcal isolates.

Implications:

  • IPD predominantly affects infants, with a clear peak incidence in the first two years of life.
  • Specific pneumococcal serotypes (19, 14, 6) are key drivers of disease in this pediatric population.
  • Understanding serotype prevalence is crucial for developing targeted prevention strategies and vaccines.

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