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Updated: Jan 19, 2026

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
Published on: January 12, 2024
The new MATH: homology suggests shared binding surfaces in meprin tetramers and TRAF trimers
Maria Sunnerhagen1, Sharon Pursglove, Malin Fladvad
1Molecular Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden. maria.sunnerhagen@mbb.ki.se
Abstract:
Although apparently functionally unrelated, intracellular TRAFs and extracellular meprins share a region with conserved meprin and traf homology, MATH(1). Both TRAFs and meprins require subunit assembly for function. By structural analysis of the sequences, we provide an explanation of how meprins, which form tetramers, and TRAF molecules, which form trimers, can share homology. Our analysis suggests it is highly likely that the same oligomerization surface is used. The analysis has implications for the widely distributed group of proteins containing MATH domains.
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