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Related Experiment Videos

Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis.

Sashwati Roy1, Beatrice H Lado, Savita Khanna

  • 1Laboratory of Molecular Medicine, Department of Surgery and Molecular and Cellular Biochemistry, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 W. 12th Avenue, Columbus 43210, USA.

FEBS Letters
|October 22, 2002
PubMed
Summary

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Tocotrienols, a form of vitamin E, are bioavailable to fetal and maternal brains during pregnancy. This study identified vitamin E-sensitive genes in developing fetal brains, highlighting their importance for neurological function.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Nutritional Science

Background:

  • Vitamin E, comprising tocopherols and tocotrienols, is crucial for neurological health.
  • Tocotrienols exhibit more potent neuroprotective properties compared to tocopherols.
  • Understanding vitamin E's role in fetal brain development is essential.

Purpose of the Study:

  • To determine the bioavailability of oral tocotrienol supplementation in pregnant rats' fetal and maternal brains.
  • To investigate the impact of altered dietary vitamin E on the gene expression profile of developing fetal brains.
  • To identify specific genes in the fetal brain responsive to vitamin E.

Main Methods:

  • Oral administration of tocotrienols to pregnant rats.
  • Analysis of tocotrienol levels in maternal and fetal brain tissues.

Related Experiment Videos

  • GeneChip microarray expression profiling of developing fetal brains.

    • Main Results:

    • Dietary tocotrienols were found to be bioavailable to both maternal and fetal brains.
    • Fetal brain tissue showed higher enrichment of tocotrienols compared to maternal brain tissue.
    • A distinct set of vitamin E-sensitive genes in the developing rat fetal brain was identified.

    Conclusions:

    • Dietary tocotrienols can cross the placental barrier and reach fetal and maternal brain tissues.
    • Fetal brain accumulation of tocotrienols suggests a critical role during development.
    • The identified vitamin E-sensitive genes provide insights into the molecular mechanisms of tocotrienol-mediated neuroprotection in fetal brains.