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[Olanzapine improves chorea in patients with Huntington's disease]
F J Jiménez-Jiménez1, M de Toledo, I Puertas
1Servicio de Nurología, Hospital Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España. fjimenezj@meditex.es
Revista De Neurologia
|October 22, 2002
Abstract
Introduction:
The main treatment for choreatic movements associated to Huntington s disease are the neuroleptic drugs, however, its use causes long term troubles.
Case Reports:
We describe two patients with a predominantly choreic Huntington s disease, who experience improvement of choreatic movements after introduction of olanzapine to their treatment, being this drug well tolerated.
Conclusions:
The improvement of chorea suggests that olanzapine has a dopaminergic D2 receptors blocking action.