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Related Experiment Videos

Leser-Trelat sign.

Can Ceylan1, Sibel Alper, Işil Kilinç

  • 1Department of Dermatology, University of Ege, Medical Faculty, Izmir, Turkey. salper@med.ege.edu.tr

International Journal of Dermatology
|October 23, 2002
PubMed
Summary

A 74-year-old male with lung squamous cell carcinoma presented with skin lesions. Dermatological examination revealed basal cell carcinoma, seborrheic keratoses, and acanthosis nigricans, highlighting potential paraneoplastic syndromes.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • A 74-year-old male diagnosed with advanced lung squamous cell carcinoma (stage 3b) was evaluated for new-onset itchy papules and a nasal lesion.
  • The patient had a significant smoking history and was being treated for heart insufficiency.

Observation:

  • Dermatological examination revealed an ulcerated nasal lesion, linearly distributed lesions on the thorax resembling seborrheic keratoses, and velvety plaques in the axillary folds.
  • Histopathological analysis confirmed basal cell carcinoma on the nose, seborrheic keratosis-like lesions, and acanthosis nigricans in the axillae.

Findings:

  • Histopathology confirmed solid-type basal cell carcinoma on the nasal apex.
  • Lesions on the thorax were consistent with seborrheic keratoses.
  • Axillary lesions were diagnosed as acanthosis nigricans.

Implications:

  • This case highlights the importance of dermatological evaluation in cancer patients, as skin manifestations can indicate underlying malignancy or associated conditions.
  • The co-occurrence of basal cell carcinoma, seborrheic keratoses, and acanthosis nigricans in a patient with lung cancer warrants further investigation into potential paraneoplastic syndromes.
  • Early detection and management of these skin conditions are crucial for patient well-being and potentially improving oncological outcomes.

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