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Antibiotic tolerance in pneumococci.

Benriques Henriques Normark1, S Normark

  • 1Swedish Institute for Infectious Disease Control and Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm Sweden. birgitta.henriques@smiki.se

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|October 23, 2002
PubMed
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Antibiotic-induced bacterial killing involves a self-destruction pathway. Impaired pathways lead to antibiotic tolerance, with capsular polysaccharides potentially regulating this lysis process.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Bacterial Pathogenesis

Background:

  • Lytic antibiotics like penicillin and vancomycin trigger self-killing in bacteria.
  • This bacterial suicide involves non-lytic and lytic processes, with non-lytic pathways potentially activating murein hydrolases.

Purpose of the Study:

  • To investigate the mechanisms of antibiotic-induced bacterial killing and tolerance.
  • To explore the role of signaling pathways and capsular polysaccharides in bacterial lysis and tolerance.

Main Methods:

  • Analysis of bacterial mutants with altered antibiotic-induced killing.
  • Investigation of murein hydrolase activity in clinical isolates of antibiotic-tolerant Streptococcus pneumoniae.

Main Results:

Related Experiment Videos

  • Disturbances in bacterial suicide pathways can result in antibiotic tolerance.
  • In a vancomycin-tolerant isolate, capsular polysaccharide production negatively controlled murein hydrolase activity.

Conclusions:

  • Capsular polysaccharide expression may influence the extent of bacterial lysis following antibiotic exposure.
  • Understanding these pathways is crucial for combating antibiotic tolerance in bacterial infections.