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Related Experiment Videos

Humoral immunity and bronchiectasis.

A Stead1, J G Douglas, C J Broadfoot

  • 1Aberdeen College, Gallowgate Centre, Aberdeen, UK.

Clinical and Experimental Immunology
|October 23, 2002
PubMed
Summary

Antibody deficiency is uncommon in adults with bronchiectasis. This study found that routine immunological testing for antibody deficiency in these patients is not generally recommended, especially after age 40.

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Area of Science:

  • Immunology
  • Pulmonology
  • Medical Diagnostics

Background:

  • Bronchiectasis is a known complication of primary antibody deficiency.
  • The frequency of antibody deficiency as a cause of bronchiectasis is not well-defined.
  • Assessing the need for immunological investigation in bronchiectasis patients is important.

Purpose of the Study:

  • To investigate the humoral immune status of bronchiectasis patients.
  • To determine the frequency of significant antibody deficiency in this cohort.
  • To assess the appropriateness of routine immunological investigations for bronchiectasis.

Main Methods:

  • Serum immunoglobulins, IgG subclasses, and specific antibodies to Haemophilus influenzae and Streptococcus pneumoniae were measured in 56 outpatients.
  • Vaccination responses were quantified in patients with low antibody levels.
  • Patients had a mean age of 59.6 years.

Main Results:

  • Three patients (3/56) had low total serum IgG.
  • Thirteen patients (13/56) had IgG subclass deficiencies, most commonly IgG4 (9/56).
  • Twenty-nine patients (29/56) had low basal specific polysaccharide antibody levels, with one showing a specific defect in response to pneumococcal polysaccharide vaccine.

Conclusions:

  • Antibody deficiency is an uncommon etiological factor in bronchiectasis beyond the fourth decade.
  • Routine detailed investigation of humoral immune status is not generally justified in adult bronchiectasis patients.
  • The findings suggest a selective approach to immunological testing in this population.

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