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[Expression of proliferating cell nuclear antigen in craniopharyngioma and tumor recurrence]
Jun Pan1, Song-Tao Qi, Yong-Jian Deng
1Department of Neurosurgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Objective:
To investigate proliferating cell nuclear antigen labeling indices (PCNA-LI) in craniopharyngiomas in association with tumor recurrence.
Methods:
Immunohistochemistry was employed to examine the expression of PCNA in 43 craniopharyngioma samples of different pathological types, and the relationship between PCNA-LI and tumor recurrence was evaluated.
Results:
PCNA-LI was much higher in adamantinous tumors than in squamous papillary tumors that did not give rise to postoperative recurrence. Although PCNA-LI was higher in the recurrent lesions than in the primary tumor in adamantinoma group, the difference was not statistically significant.
Conclusions:
Craniopharyngioma cells with different pathological features may possess varied proliferating potentials, and active proliferation is the main factor for postoperative recurrence of adamantinoma.
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