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Updated: Jan 28, 2026

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts
Published on: April 13, 2022
[Development of artificial bone made from nacre and polylactic acid and property assessment]
1Department of Spinal and Orthopaedics Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Objective:
To explore a new bone substitute for bone grafting and evaluate its properties.
Methods:
Pressurized molding of nacre, polylactic acid and NaCl that were proportionally mixed was performed to obtain the bone grafting material, and its properties as porosity, pore size and mechanical strength were compared with those of the material prepared by solvent casting.
Results:
Compared with that of the material made by solvent casting, the mechanical strength of the new artificial bone material was 10-fold stronger with an average porosity rate of 47.65%, pore size of 218.83 micrometer compressive strength of 16.10 MPa and flexural strength of 60.18 MPa.
Conclusion:
The new technique adopted in this study can effectively enhance the biomechanics of the artificial bone material, which can be suitable for repairing bone defect.
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