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Related Experiment Videos

Creatine supplementation influences substrate utilization at rest.

M Erik Huso1, Jeffrey S Hampl, Carol S Johnston

  • 1Department of Nutrition, Arizona State University, Mesa, Arizona 85212, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 23, 2002
PubMed
Summary

Creatine supplementation during weight training increased carbohydrate oxidation and fat-free mass in active men. However, creatine intake was associated with inhibited fat mass loss compared to placebo.

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Area of Science:

  • Exercise Physiology
  • Nutritional Biochemistry

Background:

  • Creatine is a popular supplement for enhancing athletic performance.
  • Its effects on substrate utilization and body composition during resistance training require further investigation.

Purpose of the Study:

  • To investigate the influence of creatine supplementation on substrate utilization during rest in active men undergoing weight training.
  • To assess the effects of creatine on body composition and strength.

Main Methods:

  • A double-blind, placebo-controlled crossover study.
  • Ten active men completed 12 weeks of weight training with creatine or placebo supplementation.
  • Body composition, substrate utilization, and strength were measured at multiple time points.

Main Results:

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  • Creatine supplementation significantly increased 1-RM bench press strength and total body mass.
  • Both creatine and placebo increased fat-free mass, but only placebo significantly decreased fat mass.
  • Creatine supplementation led to increased carbohydrate oxidation and a trend towards increased respiratory exchange ratio.

Conclusions:

  • Creatine enhances strength and muscle mass gains during weight training.
  • Creatine supplementation may alter substrate utilization, potentially inhibiting fat mass loss.
  • Further research is needed to understand the mechanisms behind creatine's effects on substrate metabolism and body composition.