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Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal
Gael Daoudal1, Yasuhiro Hanada, Dominique Debanne
1Neurobiologie des Canaux Ioniques, Institut National de la Santé et de la Recherche Médicale U464, Institut Fédératif de Recherche Jean Roche, Université de la Méditerranée, Bd P. Dramard, 13916 Marseille cedex 20, France.
Abstract:
Integration of synaptic excitation to generate an action potential (excitatory postsynaptic potential-spike coupling or E-S coupling) determines the neuronal output. Bidirectional synaptic plasticity is well established in the hippocampus, but whether active synaptic integration can display potentiation and depression remains unclear. We show here that synaptic depression is associated with an N-methyl-d-aspartate receptor-dependent and long-lasting depression of E-S coupling. E-S depression is input-specific and is expressed in the presence of gamma-aminobutyric acid type A and B receptor antagonists. In single neurons, E-S depression is observed without modification of postsynaptic passive properties. We conclude that a decrease in intrinsic excitability underlies E-S depression and is synergic with glutamatergic long-term depression.