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Enhancement of use-dependent plasticity by D-amphetamine
L Sawaki1, L G Cohen, J Classen
1Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA.
Neurology
|October 23, 2002
Abstract:
In healthy individuals, motor training can elicit use-dependent plasticity. Here the authors studied six subjects in whom training alone failed to elicit this effect. Administration of a single dose of 10 mg of D-amphetamine preceding training led to use-dependent plasticity in a subgroup of these subjects. Using pharmacologic interventions to enhance the effects of motor training might help rehabilitative efforts in patients in whom training alone fails.