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Serial fMRI of adaptive changes in primary sensorimotor cortex following thumb reconstruction
M Manduch1, M Bezuhly, D J Anastakis
1Faculty of Medicine, University of Toronto, Toronto, Canada.
Neurology
|October 23, 2002
Abstract:
Serial fMRI was performed in a patient who underwent transfer of the left great toe to the hand following amputation of the right thumb. Motor activation within the primary sensorimotor cortex (SMC) of both hemispheres was quantified over 2 years, showing a transient increase in contralateral but not ipsilateral primary SMC. The temporal pattern of motor cortical activation observed in this patient may represent a "signature" of good functional recovery.