Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Goblet cells in the developing human nose.

J Poulsen, M Tos

    Acta Oto-Laryngologica
    |November 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Goblet cells develop in the fetal nasal cavity starting at 13 weeks, spreading throughout the respiratory region by 30 weeks. Their density varies by location, with significant increases expected around birth.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impact of fat source and dietary fibers on feed intake, plasma metabolites, litter gain and the yield and composition of milk in sows.

    Animal : an international journal of animal bioscience·2016
    Same author

    Hearing outcomes of vestibular schwannoma patients managed with 'wait and scan': predictive value of hearing level at diagnosis.

    The Journal of laryngology and otology·2010
    Same author

    Mobile, one stage, bilateral ear surgery for chronic otitis media patients in remote areas.

    The Journal of laryngology and otology·2009
    Same author

    Effect of diathermy on pain and healing in tonsillectomy, compared with other methods of haemostasis: a randomised study.

    The Journal of laryngology and otology·2008
    Same author

    Change in hearing during 'wait and scan' management of patients with vestibular schwannoma.

    The Journal of laryngology and otology·2007
    Same author

    Erectile dysfunction after perineal compression in young men undergoing internal fixation of femur fractures.

    International journal of impotence research·2006
    Same journal

    Vasopressin type-2 receptor mRNA expressions in endolymphatic sac and temporal bone cT findings in Meniere's disease.

    Acta oto-laryngologica·2026
    Same journal

    The impact of climate and environmental factors on the incidence of Bell's palsy: a nationwide population study.

    Acta oto-laryngologica·2026
    Same journal

    Association between low temporalis muscle thickness and chemoradiotherapy-induced leukopenia in head and neck squamous cell carcinoma.

    Acta oto-laryngologica·2026
    Same journal

    Auditory Outcomes After Simultaneous Translabyrinthine Vestibular Schwannoma Resection and Cochlear Implantation: A Prospective Case Series.

    Acta oto-laryngologica·2026
    Same journal

    CT imaging parameters of the oval window region can predict the extent of stapes footplate exposure in patients with otosclerosis.

    Acta oto-laryngologica·2026
    Same journal

    Congenital middle ear anomalies: endoscopic outcomes, facial nerve anomalies, and bilateral consistency in 41 ears.

    Acta oto-laryngologica·2026
    See all related articles

    Area of Science:

    • Human Embryology and Development
    • Respiratory System Anatomy
    • Histology of Nasal Mucosa

    Background:

    • Respiratory epithelium differentiation is a complex process.
    • Goblet cells are crucial for mucus production in the nasal cavity.
    • Understanding the developmental timeline of goblet cells is essential for pediatric respiratory health.

    Purpose of the Study:

    • To investigate the developmental timeline of goblet cells in the fetal and premature nasal mucosa.
    • To map the spread, distribution, and density of goblet cells from the 9th to the 30th week of gestation.
    • To compare goblet cell density across different regions of the nasal cavity during early development.

    Main Methods:

    • Analysis of nasal mucosa from 56 fetuses and premature infants (9-30 weeks gestation).

    Related Experiment Videos

  • Histological staining techniques including PAS-alcian blue, PAS, and osmium whole-mount methods.
  • Microscopic examination to assess goblet cell formation, spread, distribution, and density.

    • Main Results:

    • Goblet cell formation initiated anteriorly in the nasal vestibule around the 13th week.
    • Cells spread posteriorly in a consistent pattern, reaching the entire respiratory region by 30 weeks.
    • Highest goblet cell density observed in the anterior/inferior septum, lateral wall, and inferior/middle meatuses; lower density on conchae and olfactory region junction.

    Conclusions:

    • Goblet cell development follows a predictable pattern during fetal nasal cavity maturation.
    • Significant regional variations in goblet cell density are established by 30 weeks gestation.
    • Goblet cell formation represents the final stage of respiratory epithelium differentiation, occurring after ciliated cell development.