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Role of mitochondrial dysfunction in Alzheimer's disease
Rudy Castellani1, Keisuke Hirai, Gjumrakch Aliev
1Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA. rjc8@po.cwru.edu
Journal of Neuroscience Research
|October 23, 2002
Abstract:
Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease.