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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

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[Chemically-induced differentiation of the tumor cell lines]

A G Anisimov1, T O Volkova, A A Chekmasova

  • 1Petrozavodsk State University, pr. Lenina 33, Petrozavodsk, 185640 Russia.

Ontogenez
|October 24, 2002
PubMed

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Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...