Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydrogen sulfide as a neuromodulator.

Hideo Kimura1

  • 1National Institute of Neuroscience, Kodaira, Tokyo, Japan. kimura@ncnp.go.jp

Molecular Neurobiology
|October 24, 2002
PubMed
Summary

Hydrogen sulfide (H2S), once known only as a toxic gas, is now recognized as a key physiological messenger in the brain. Research shows H2S influences memory and smooth muscle function, highlighting its novel roles.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AlV<sub>3</sub>/Cu<sub>9</sub>Al<sub>4</sub> Composite Derived from Al-V-Cu Precursors for Enhancing the Hydrogen Storage Properties of MgH<sub>2</sub>.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Clonal Stabilization Reveals a DAO/3MST-Expressing MDCK Subpopulation With Robust d-Cysteine-Mediated H<sub>2</sub>S Production.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Physiological Roles of Hydrogen Sulfide/Polysulfides and Regulation of their Production.

Handbook of experimental pharmacology·2026
Same author

Hydrogen sulfide/polysulfides signaling and neuronal diseases.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2025
Same author

Correction: Initiating Binary Metal Oxides Microcubes Electromagnetic Wave Absorber Toward Ultrabroad Absorption Bandwidth Through Interfacial and Defects Modulation.

Nano-micro letters·2025
Same author

Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity.

Redox biology·2024

Area of Science:

  • Neuroscience
  • Biochemistry
  • Physiology

Background:

  • Hydrogen sulfide (H2S) was historically recognized for its toxicity.
  • Recent discoveries reveal endogenous H2S as a significant physiological messenger in the brain.
  • High concentrations of H2S have been found in the brain, prompting further investigation.

Purpose of the Study:

  • To review recent advancements in understanding H2S as a neuromodulator and neurotransmitter.
  • To explore the role of H2S in brain functions such as memory.
  • To discuss the enzymatic pathways and regulation of H2S production.

Main Methods:

  • Identification of H2S-producing enzymes: cystathionine beta-synthase (CBS) in the brain and cystathionine gamma-lyase (CSE) in smooth muscle.
  • Investigation of CBS regulation by S-adenosyl-L-methionine (SAM), pyridoxal-5'-phosphate, and Ca2+/calmodulin pathways.
  • Analysis of H2S effects on hippocampal long-term potentiation (LTP) and corticotropin-releasing hormone (CRH) release.

Main Results:

  • H2S is produced in response to neuronal excitation.
  • H2S modulates hippocampal long-term potentiation (LTP), a key mechanism for memory formation.
  • H2S, in synergy with nitric oxide (NO), relaxes smooth muscle.
  • H2S can regulate the release of corticotropin-releasing hormone (CRH) from the hypothalamus.

Conclusions:

  • Hydrogen sulfide (H2S) plays a critical role as a neuromodulator and neurotransmitter in the central nervous system.
  • Enzymes like CBS and CSE are central to H2S production and its physiological functions.
  • H2S has diverse biological effects, impacting synaptic plasticity, memory, and vascular tone.

Related Experiment Videos