Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Venous air embolism prophylaxis with a surface-active agent.

J C Perry, E S Munson, M H Malagodi

    Anesthesia and Analgesia
    |November 1, 1975
    PubMed
    Summary

    Pluronic F-68, a surfactant, significantly reduced cardiorespiratory damage from air embolism in dogs. This finding suggests its potential benefit for surgical patients at risk of venous air embolism.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    High-throughput nuclear morphometric analysis for pig sperm quality assessment.

    Theriogenology·2026
    Same author

    Impedance Control of a 2-DOF Spherical 5-Bar Exoskeleton for Physical Human-Robot Interaction During Rehabilitation and Assessment.

    IEEE ... International Conference on Rehabilitation Robotics : [proceedings]·2023
    Same author

    Effect of top soil wettability on water evaporation and plant growth.

    Journal of colloid and interface science·2015
    Same author

    Cardiovascular function alterations induced by acute paradoxical sleep deprivation in rats.

    Clinical and experimental hypertension (New York, N.Y. : 1993)·2014
    Same author

    Control processes and defense mechanisms.

    The Journal of psychotherapy practice and research·2012
    Same author

    Mating stimulates female feeding: testing the implications for the evolution of nuptial gifts.

    Journal of evolutionary biology·2011

    Area of Science:

    • Anesthesiology
    • Cardiovascular Physiology
    • Respiratory Physiology

    Background:

    • Venous air embolism (VAE) poses a significant risk during surgical procedures.
    • Current management strategies for VAE are limited.
    • Nonionic surfactants may offer a protective effect against VAE.

    Purpose of the Study:

    • To investigate the protective effects of Pluronic F-68 against VAE.
    • To evaluate the impact of Pluronic F-68 on cardiorespiratory parameters during VAE.

    Main Methods:

    • Twenty-one anesthetized dogs received pentobarbital.
    • VAE was induced via bolus injection and constant-rate IV infusion of air.
    • Hemodynamic and respiratory parameters were monitored before and after Pluronic F-68 administration.

    Related Experiment Videos

    Main Results:

    • Pluronic F-68 significantly reduced changes in aortic, pulmonary artery, and right ventricular pressures.
    • Cardiac output and end-tidal CO2 concentration changes were attenuated by Pluronic F-68.
    • Wasted ventilation and blood surface tension alterations were less pronounced in treated animals.

    Conclusions:

    • Pluronic F-68 demonstrates a protective effect against the cardiorespiratory consequences of VAE in a canine model.
    • This surfactant may be a valuable adjunct for surgical patients with an elevated risk of VAE.