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[Predictive factors for invasive pnuemococcal disease: a case-control study].
C Pérez Méndez1, G Solís Sánchez, D Miguel Martínez
1Servicios de Pediatría, Hospital de Cabueñes, Gijón, España. cperez@hcab.insalud.es
Anales Espanoles De Pediatria
|October 24, 2002
Summary
Invasive pneumococcal disease (IPD) is highly prevalent in Spanish children, with occult bacteremia being the most common diagnosis. High temperature, malaise, age 6-36 months, and elevated absolute neutrophil count (ANC) predict IPD risk.
Area of Science:
- Pediatric Infectious Diseases
- Epidemiology
- Bacteriology
Context:
- Streptococcus pneumoniae causes significant childhood morbidity.
- Data on invasive pneumococcal disease (IPD) incidence in Spain are limited.
- This study addresses the clinical and epidemiological features of IPD in a Spanish health district.
Purpose:
- To describe the clinical and epidemiological characteristics of IPD in febrile children.
- To identify predictive factors for IPD in children presenting to a hospital Emergency Department.
Summary:
- An observational, retrospective, case-control study was conducted from 1992-2001.
- Seventy-six cases of IPD were analyzed, revealing high incidence rates (174.1/100,000 in <24 months).
- Key predictors for IPD included fever ≥39°C, malaise, age 6-36 months, and absolute neutrophil count (ANC) ≥10,000 cells/mm³.
Impact:
- The incidence of IPD in the studied region exceeds other European areas.
- Occult bacteremia was the most frequent diagnosis, and mortality was low (1.3%).
- Elevated ANC emerged as the strongest predictor for invasive pneumococcal disease in children.