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[Periodic fever]

I Mongil Ruiz1, V Canduela Martínez

  • 1Hospital de Laredo. Cantabria. España. imongil@hlrd.insalud.es

Anales Espanoles De Pediatria
|October 24, 2002
PubMed

Insights

Periodic fever syndromes involve recurrent fevers, challenging diagnosis against infections. This review classifies hereditary and non-hereditary types, aiding understanding and treatment.

Area of Science:

  • Medicine
  • Genetics
  • Immunology

Background:

  • Periodic fever involves recurrent episodes of fever, often difficult to differentiate from infections, malignancies, or connective tissue diseases.
  • These conditions are uncommon but present diagnostic challenges in clinical practice.
  • A comprehensive understanding requires consolidating dispersed literature on these varied presentations.

Purpose of the Study:

  • To systematically review and categorize diverse periodic fever syndromes.
  • To provide a consolidated perspective on both hereditary and non-hereditary forms.
  • To highlight diagnostic challenges and recent advancements in understanding genetic bases.

Main Methods:

  • Literature review and classification of periodic fever syndromes.
  • Categorization into hereditary and non-hereditary groups based on existing studies.
  • Synthesis of clinical and genetic information from dispersed literature.

Main Results:

  • Periodic fever syndromes were classified into two main categories: hereditary and non-hereditary.
  • Hereditary examples include familial Mediterranean fever, hyper-IgD syndrome, and others.
  • Non-hereditary examples include PFAPA syndrome, cyclic neutropenia, and others.

Conclusions:

  • Accurate diagnosis of periodic fever syndromes is crucial and can be challenging.
  • Advances in molecular and genetic knowledge of hereditary forms aid diagnosis and treatment.
  • This review consolidates information to offer a detailed perspective on these conditions.

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