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Effective artificial proteases synthesized by covering silica gel with aldehyde and various other organic groups
Hyunsook Kim1, Myoung-soon Kim, Hyesun Paik
1School of Chemistry and Center for Molecular Catalysis, Seoul National University, Republic of Korea.
Bioorganic & Medicinal Chemistry Letters
|October 24, 2002
Abstract:
Organic artificial proteases with broad substrate specificity were synthesized by covering the surface of silica gel with aldehyde and the functional groups present in amino acids. The artificial proteases hydrolyzed ovalbumin, albumin, hemoglobin, gamma-globulin with half-lives as short as 50 min at 25 degrees C or 7 min at 50 degrees C.