Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental changes in lysosome morphology and function Leishmania parasites.

Ross F Waller1, Malcolm J McConville

  • 1Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Vic 3010, Australia.

International Journal for Parasitology
|October 24, 2002
PubMed
Summary

Researchers discovered a novel multivesicular tubule lysosome in Leishmania parasites. This organelle plays a dynamic role in parasite growth and differentiation, offering new insights into the endocytic pathway.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell cycle checkpoint activity in the malaria parasite <i>Plasmodium falciparum</i>.

mSphere·2026
Same author

The spatial proteome of the Plasmodium falciparum schizont illuminates the composition and evolutionary trajectories of its organelles.

Nature communications·2026
Same author

An integrative spatial multi-omic workflow for unified analysis of tumor tissue.

Cell reports methods·2026
Same author

Intralysosomal pathogens differentially influence the proteolytic potential of their niche.

Infection and immunity·2025
Same author

Bridging a Gap in Marine Sulfur Cycling: Discovery of a d-Cysteinolic Acid Degradation Pathway.

Journal of the American Chemical Society·2025
Same author

Semi-supervised Bayesian integration of multiple spatial proteomics datasets.

PLoS computational biology·2025

Area of Science:

  • Parasitology
  • Cell Biology
  • Molecular Biology

Background:

  • The endocytic pathway in Leishmania parasites is crucial for their survival and virulence.
  • Recent advancements in developing compartment-specific markers have enabled detailed investigation of this pathway.

Purpose of the Study:

  • To review recent insights into the Leishmania lysosome.
  • To discuss its organization within the endocytic pathway.
  • To highlight its stage-specific functions and biogenesis.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of newly developed markers for the Leishmania endocytic pathway.
  • Integration of data on organelle dynamics during parasite growth and differentiation.

Related Experiment Videos

Main Results:

  • Discovery of a novel multivesicular tubule lysosome in Leishmania promastigotes.
  • Identification of a highly dynamic role for this organelle during parasite growth and differentiation.
  • Elucidation of the lysosome's organization within the parasite's endocytic pathway.

Conclusions:

  • The Leishmania lysosome is a dynamic organelle with significant roles in parasite biology.
  • Understanding its organization, function, and biogenesis provides key insights into parasite survival.
  • This review consolidates current knowledge and highlights areas for future research.