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Developmental changes in lysosome morphology and function Leishmania parasites
Ross F Waller1, Malcolm J McConville
1Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Vic 3010, Australia.
International Journal for Parasitology
|October 24, 2002
Abstract:
The endocytic pathway of Leishmania parasites has recently come under intense research focus through the development of several markers for various compartments of this pathway. Through these studies a novel multivesicular tubule lysosome has been discovered in promastigote-stage parasites. This organelle has a highly dynamic role during parasite growth and differentiation. This review discusses recent insights into the Leishmania lysosome with respect to its organisation within the endocytic pathway, stage-specific functions, and biogenesis.