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Lipoprotein-associated estrogens.

Matti J Tikkanen1, Veera Vihma, Matti Jauhiainen

  • 1Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, 00290, Helsinki, Finland. matti.tikkanen@hus.fi

Cardiovascular Research
|October 24, 2002
PubMed
Summary
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Fatty acid-conjugated estrogens, insoluble in water, are transported within lipoproteins. Research explores their roles as antioxidants, hormone storage, and novel transport systems, with new methods for detection.

Area of Science:

  • Endocrinology and Metabolism
  • Lipid Biochemistry
  • Cardiovascular Research

Background:

  • Discovery of fatty acid-esterified hormonal steroids raises questions about their physiological functions.
  • Water-insolubility necessitates their association with lipoprotein particles for circulation.

Purpose of the Study:

  • To investigate the physiological roles of fatty acid-esterified estrogens.
  • To explore their potential functions as antioxidants, storage mechanisms, and novel transport systems.

Main Methods:

  • Investigated estrogen esterification catalyzed by lecithin:cholesterol acyltransferase (LCAT) associated with HDL.
  • Examined estradiol ester transfer from HDL to LDL via cholesteryl ester transfer protein (CETP).
  • Developed quantitative methods for determining estradiol fatty acid esters in human body fluids.

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Main Results:

  • Estrogen esterification is linked to LCAT and HDL.
  • Estradiol esters are transferred between lipoproteins (HDL to LDL) mediated by CETP.
  • Preliminary data suggest plant estrogens also form lipophilic derivatives incorporated into lipoproteins.

Conclusions:

  • Fatty acid-esterified estrogens may act as lipoprotein-bound antioxidants.
  • These compounds could serve as a storage mechanism for hormones within lipoproteins and adipose tissue.
  • A novel hormone transport system utilizing lipoproteins and their receptors is proposed.