Jove
Visualize
Contact Us

Related Experiment Videos

Vigabatrin for infantile spasms.

Wendy G Mitchell1, Namrata S Shah

  • 1Neurology Division, Childrens Hospital Los Angeles, Los Angeles, California 90027, USA.

Pediatric Neurology
|October 24, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative effectiveness of second-line treatments for epileptic spasms.

Epilepsia·2025
Same author

Sexual Health Education and Quality of Counseling in Pediatric-Onset Multiple Sclerosis.

Pediatric neurology·2024
Same author

Safety and tolerability of intravenous immunoglobulin infusion in Down syndrome regression disorder.

American journal of medical genetics. Part A·2024
Same author

Impact of endocrine dysregulation on disability and non-motor symptoms in pediatric onset multiple sclerosis.

Frontiers in neurology·2023
Same author

An International Pediatric-Onset Opsoclonus-Myoclonus Ataxia Syndrome Registry and Clinical Research Network: Development, Progress, and Vision.

Pediatric neurology·2023
Same author

Association of rare variants in genes of immune regulation with pediatric autoimmune CNS diseases.

Journal of neurology·2022
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Vigabatrin effectively treats infantile spasms in infants. Starting with a low dose and gradually increasing is more advantageous than a high initial dose, as response appears dose-independent.

Area of Science:

  • Pediatric Neurology
  • Pharmacology

Background:

  • Infantile spasms are a severe epilepsy syndrome in infants.
  • Vigabatrin is an antiepileptic drug used to treat infantile spasms.

Purpose of the Study:

  • To evaluate the efficacy and optimal dosing strategy of vigabatrin for infantile spasms in a cohort of 20 infants.

Main Methods:

  • Retrospective review of 20 infants treated with vigabatrin for infantile spasms.
  • Dosing initiated at 125-250 mg/day, gradually increased to a target of 100 mg/kg/day.
  • Video electroencephalogram (EEG) used to assess spasm cessation and hypsarrhythmia resolution.

Main Results:

  • Twelve out of 20 infants (60%) responded with cessation of spasms and hypsarrhythmia resolution.

Related Experiment Videos

  • Responses were observed at doses ranging from 25-135 mg/kg/day (median 58 mg/kg/day).
  • Six infants showed partial responses, and two had no response; three developed new seizure types.

    • Conclusions:

    • Vigabatrin is an effective and well-tolerated treatment for infantile spasms.
    • Response to vigabatrin appears to be dose-independent.
    • Initiating treatment with a low, gradually increasing dose is recommended over a fixed high initial dose.