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Updated: Sep 28, 2026

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process
Published on: March 21, 2014
Manufacturing factors affecting the drug delivery function of thermo-responsive membrane prepared by adsorption of
Shan-Yang Lin1, Hsiu-Li Lin, Mei-Jane Li
1Biopharmaceutics Laboratory, Department of Medical Research and Education, Veterans General Hospital--Taipei, Taipei, Taiwan. sylin@vghtpe.gov.tw
Abstract:
A binary mixture of cholesteric oleyl carbonate (COC) and cholesteryl nonanoate (CN) with a weight ratio of 36% and 64% was adsorbed onto the cellulose nitrate membrane to prepare a thermo-responsive membrane. The thermo-responsive function of these COC/CN-adsorbed membranes was evaluated by an in vitro penetration study via repeatedly exchanging the temperature cycle. The manufacturing factors for preparing these thermo-responsive membranes, such as the binary COC/CN concentration used, immersion temperature of binary COC/CN chloroform solution, immersion temperature and time period of distilled water, vacuum-drying or air-drying process, and vacuum drying temperature, have been explored. The results indicated that the immersion temperature at 23 degrees C for membrane in binary COC/CN chloroform solution with 10 min and in distilled water with 12 h was the optimal temperature for fabricating the on-off thermo-responsive membranes prepared either by 22% or 25% concentration of binary COC/CN mixture. A good thermo-responsive function was further evidenced for these COC/CN-adsorbed membranes via vacuum-drying at 65 degrees C for 1 h. A possible mechanism concerning the thermal-dependent molecular motion, orientation and/or alignment of binary COC/CN mixture entrapped into the membrane may play an important role for the thermo-responsive behavior.
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