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Pediatric localized amyloidosis in mesopharynx.

Masahiro Takahashi1, Hideki Matsuda, Keiko Ito

  • 1Department of Otolaryngology, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. masahir@qd5.so-net.ne.jp

International Journal of Pediatric Otorhinolaryngology
|October 24, 2002
PubMed
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This study reports a rare case of primary localized amyloidosis in a 12-year-old girl, the third pediatric case documented. The pharyngeal mass showed no change over 24 months without treatment.

Area of Science:

  • Otorhinolaryngology
  • Pathology
  • Immunohistochemistry

Background:

  • Primary localized amyloidosis is a rare condition.
  • Amyloidosis of the mesopharynx is exceptionally rare, particularly in pediatric patients.

Observation:

  • A 12-year-old girl presented with a pharyngeal mass detected during a school health examination.
  • Physical examination identified a mass within the faucial tonsil.
  • Histological examination revealed amyloid deposition and chronic inflammatory cell infiltration.

Findings:

  • Immunohistochemical analysis confirmed the amyloid deposit was positive for amyloid P component (AP) and negative for amyloid L (AL).
  • The mesopharyngeal mass remained unchanged over a 24-month observation period without any intervention.

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  • The patient was asymptomatic, and no treatment was administered.

    • Implications:

    • This case contributes to the limited literature on pediatric mesopharyngeal amyloidosis.
    • The findings highlight the potential for asymptomatic presentation and stability of amyloid P component-positive amyloidosis in the mesopharynx.
    • Further research may elucidate the specific mechanisms and long-term behavior of this rare condition in children.