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AML1 amplification in a case of childhood acute lymphoblastic leukemia
Frédéric Morel1, Angèle Herry, Marie-Josée Le Bris
1Laboratoire de Cytogénétique, Faculté de Médecine, Université de Bretagne Occidentale, 22 Avenue Camille Desmoulins, F-29285 Brest cedex, France.
Cancer Genetics and Cytogenetics
|October 24, 2002
Abstract:
We report an 8-year-old girl with B-cell acute lymphoblastic leukemia (ALL). The blast cell karyotype at diagnosis included a marker chromosome revealed by fluorescence in situ hybridization to be a derivative of chromosome 21. A high level amplification of the AML1 gene was identified, but it disappeared upon complete remission. This rare but recurrent abnormality warrants research of B-cell ALL, especially when a marker chromosome is present in the blast cell karyotype.