Defective cardiac ion channels: from mutations to clinical syndromes

A hERG blocker facilitates K+ channel current by promoting pore opening while blocking.

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A hERG Blocker Facilitates K+ Channel Current by Agonizing Pore Opening while Blocking.

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Defective cardiac ion channels: from mutations to clinical syndromes

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A hERG blocker facilitates K+ channel current by promoting pore opening while blocking.

Optical digital twins for disease prevention, diagnosis, therapy, and intervention.

BoltzOmics: Predicting genetic variant effects on drug binding with Boltz-2.

Congenital heart defects - diagnosis and treatment.

Large-scale synthetic data enable digital twins of human excitable cells.

A hERG Blocker Facilitates K+ Channel Current by Agonizing Pore Opening while Blocking.

Myotonic Muscle Activity Drives a Persistent Pain State Responsive to NaV1.8-directed Analgesics.

Anti-PLA2R autoantibodies induce complement activation via IgG subclass-dependent epitope pairings in membranous nephropathy.

Enhancing Gemcitabine Uptake by Promoting Dimerization of the ENT1 Transporter Improves Sarcoma Patient Response Rate.

CD8⁺ Regulatory T Cells Shorten Neutrophil Lifespan to Reduce Hemorrhagic Transformation After Ischemic Stroke.

Multiple sclerosis-associated CD226 variant disrupts vitamin D-induced type I Treg differentiation by impairing LFA-1 activation.

Conserved neuronal-like and secretory programs define the spatial architecture of gastroenteropancreatic neuroendocrine tumors.

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From a Pinched Nerve to a Fatal Prognosis: Sporadic Creutzfeldt-Jakob Disease Masquerading as Cervical Myelopathy.

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Defective cardiac ion channels: from mutations to clinical syndromes

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