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Updated: Sep 23, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Published on: May 26, 2011

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Cellular immunity to viral and fungal antigens after stem cell transplantation

Hermann Einsele1, Holger Hebart

  • 1Department of Hematology and Oncology, Abteilung II, Eberhard-Karls-Universität Tübingen, Germany. hermann.einsele@med.uni-tuebingen.de

Current Opinion in Hematology
|October 24, 2002
PubMed

Cellular immunity to viral and fungal antigens is often suppressed after stem cell transplantation. Viral infections, in particular infections with cytomegalovirus and Epstein-Barr virus, are often reactivated after allogeneic stem cell transplantation. Pathogenetic factors are immune deficiency and T-cell stimulation in the course of graft-versus-host reactions. Fungal infections are opportunistic infections derived with ubiquitous microorganisms. Immune deficiency, neutropenia, steroid treatment, and antibiotic treatment contribute to the pathogenesis. The study of viral and fungal immunity after allogeneic stem cell transplantation gives insight into the reconstitution of the immune system and tolerance.

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