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Apolipoprotein E gene polymorphism alters lipids before pancreas transplantation
Sajeev Balakrishnan1, Christopher Colling, Tab Burkman
1Diabetes, Endocrinology and Metabolism Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-3020, USA.
Transplantation
|October 24, 2002
Summary
Apolipoprotein E4 (Apo E4) genotype worsens lipid profiles in pancreas transplant candidates. However, pancreas transplantation improves lipids, negating the Apo E4 effect post-transplant.
Area of Science:
- Endocrinology
- Transplantation immunology
- Clinical biochemistry
Background:
- Pancreas transplantation (PTX) improves lipids in type 1 diabetes mellitus (T1DM) patients.
- Persistent or new hyperlipidemia can occur post-PTX.
- Apolipoprotein E (Apo E) genotype influences lipid profiles and may affect PTX outcomes.
Purpose of the Study:
- To evaluate the impact of Apo E genotype on lipid profiles in T1DM patients before and after PTX.
- To determine if Apo E polymorphism influences dyslipidemia in PTX candidates.
Main Methods:
- Prospective evaluation of fasting-lipid profiles in T1DM patients undergoing PTX evaluation.
- Analysis of lipid profiles based on Apo E genotype (E2, E3, E4 alleles).
Main Results:
- Apo E4 allele carriers had higher triglycerides, lower HDL, and higher cholesterol-to-HDL ratio pre-PTX compared to E3/3 genotype.
- Post-PTX, lipid profiles improved, eliminating significant differences between E4 carriers and E3/3 genotype.
- Apo E2 allele presence did not significantly impact fasting lipids pre- or post-PTX.
Conclusions:
- Apo E4 allele significantly worsens lipid profiles (HDL, triglycerides, cholesterol-to-HDL ratio) pre-PTX.
- Apo E2 allele has no significant effect on lipid profiles in PTX candidates.
- PTX effectively improves lipid profiles, mitigating the negative impact of Apo E4 genotype despite immunosuppression.