Related Experiment Video
Updated: Sep 28, 2026

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
Published on: May 24, 2016
Myocardial infarction and atypical Kawasaki disease in a 3-month-old infant
Trina L Peduzzi1, Raymond D Pitetti
1Department of Pediatrics, St. Barnabas Hospital, Bronx, New York, USA. tlpeduzzi@hotmail.com
Insights
Diagnosing atypical Kawasaki disease (AKD) in children is challenging, often leading to delayed treatment and severe heart complications. Early recognition is crucial to prevent conditions like coronary artery aneurysms and myocardial infarction.
Area of Science:
- Pediatric Cardiology
- Rheumatology
- Infectious Disease
Background:
- Kawasaki disease (KD) is a leading cause of acquired heart disease in children.
- Atypical Kawasaki disease (AKD) presents diagnostic challenges, often delaying critical treatment.
- Delayed diagnosis increases the risk of severe cardiovascular sequelae.
Observation:
- A 3-month-old infant presented with cardiovascular collapse.
- The infant was diagnosed with multiple coronary artery aneurysms and myocardial infarction.
- These findings were attributed to undiagnosed atypical Kawasaki disease.
Findings:
- Atypical Kawasaki disease can manifest with severe cardiovascular complications, including aneurysms and myocardial infarction.
- Diagnostic criteria for KD and AKD are essential for timely intervention.
- Cardiovascular collapse can be an initial presentation of AKD.
Implications:
- Emphasizes the need for heightened clinical suspicion for AKD in infants presenting with cardiovascular compromise.
- Highlights the importance of prompt echocardiographic evaluation in suspected cases.
- Underscores the potential for severe cardiac morbidity if AKD is not recognized and treated early.
Abstract:
Diagnosing atypical Kawasaki disease (AKD) in children is often difficult and frequently delayed. As a result, children may present with life-threatening cardiovascular complications of the disease. Such complications include myocarditis, coronary artery abnormalities (eg, aneurysms), and myocardial infarction. In this report, we describe the case of a 3-month-old infant who presented to our emergency department in cardiovascular collapse. She was found to have multiple coronary artery aneurysms and a myocardial infarction and was subsequently diagnosed with AKD. This report reviews the diagnostic criteria for Kawasaki disease and AKD, common cardiovascular sequelae, and the presentation of children with these cardiovascular complications.
Related Concept Videos
Myocarditis III: Medical Management
Myocarditis I: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Myocarditis II: Clinical Features and Diagnostic Tests
Acute Coronary Syndrome I: Introduction
Rheumatic Heart Disease I: Introduction