Reversible left ventricular dysfunction "takotsubo" cardiomyopathy related to catecholamine cardiotoxicity

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Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

Yoshihiro J Akashi1, Kiyoshi Nakazawa, Masayoshi Sakakibara

  • 1Division of Cardiology, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki-city, Kanagawa-pref, Japan. johnny@marianna-u.ac.jp

Journal of Electrocardiology
|October 24, 2002
PubMed

Insights

This study details a case of reversible left ventricular dysfunction in an elderly woman, likely caused by high catecholamine levels. The condition mimicked myocardial infarction but resolved spontaneously.

Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Persistent consciousness disturbance warrants thorough investigation.
  • Electrocardiography is crucial for diagnosing cardiac events.

Observation:

  • An 80-year-old female presented with altered consciousness and ST-segment elevation mimicking myocardial infarction.
  • Coronary angiography showed normal arteries, but left ventriculography revealed left ventricular dysfunction.
  • Elevated plasma catecholamines and cardiac autonomic dysfunction were noted.

Findings:

  • Transient left ventricular dysfunction and ST-segment elevation resolved spontaneously without specific treatment.
  • Cardiac catecholamine dynamics showed transient dysfunction on (123)I-metaiodobenzyl guanidine scintigraphy.
  • The patient experienced significant ST-segment elevation and subsequent deep inverted T waves on ECG.

Implications:

  • High catecholamine levels can induce reversible left ventricular dysfunction, mimicking acute coronary syndromes.
  • This case highlights the importance of considering endocrine causes in cardiac emergencies.
  • Understanding catecholamine effects on the heart is vital for accurate diagnosis and management.

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