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Co-occurrence of neuroblastoma and nephroblastoma in an infant with Fanconi's anemia
Heidi Bissig1, Franziska Staehelin, Markus Tolnay
1Division of Hematology/Oncology, University Children's Hospital Basel, Basel, Switzerland.
Abstract:
We report the clinical, histologic, and genetic findings of concurrent neuroblastoma and nephroblastoma in an infant with Fanconi's anemia (FA). Both tumors had characteristic chromosomal aberrations. In particular, the neuroblastoma showed a gain of chromosome 17q, considered an important factor for prognosis. But untypical genetic changes were also seen suggesting that FA as a chromosomal instability syndrome causes new and untypical chromosomal variations in different tumors. The present case is unique because the simultaneous occurrence of a neuroblastoma and nephroblastoma with FA has not yet been described.
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