Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signal transduction by type I interferons.

Michael David1

  • 1Division of Biological Sciences, and UCSD Cancer Center, University of California, San Diego 92093-0322, USA. midavid@ucsd.edu

Biotechniques
|October 25, 2002
PubMed
Summary

Type I interferons (IFN) are crucial cytokines with antiviral and immune functions. This review details the molecular mechanisms behind their biological responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the barriers to optimal survivorship care for people living with Cancer in NSW.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Cervical cancer burden and elimination readiness in the US-affiliated Pacific Islands: A structured narrative review.

Cancer epidemiology·2026
Same author

Evaluating Prognostic Factors for Sex Differences in Lung Cancer Survival: A Retrospective Analysis of Real-World Data in Australia.

Clinical lung cancer·2026
Same author

Trajectories of health-related quality of life after cancer diagnosis in a cohort of Australian women: a longitudinal study.

Health and quality of life outcomes·2026
Same author

Cardiovascular Disease Mortality Patterns Among People With Cancer in New South Wales, Australia: A Population-Wide Data Linkage Study.

Cancer medicine·2026
Same author

Comorbidity patterns and health-related quality of life in a cohort of Australian women cancer survivors.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2026

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Signaling

Background:

  • Interferons (IFNs) are cytokines with diverse biological functions.
  • Type I IFNs (IFN-alpha, IFN-beta, IFN-omega, IFN-tau) and Type II IFN (IFN-gamma) are distinct classes.
  • These cytokines modulate cellular responses, including antiviral, antiproliferative, and immunomodulatory effects.

Purpose of the Study:

  • To summarize recent advancements in understanding Type I interferon signaling.
  • To elucidate the molecular events mediating biological responses to Type I IFNs.

Main Methods:

  • Literature review of molecular and cellular studies.
  • Analysis of signaling pathways activated by Type I IFNs.

Main Results:

  • Detailed description of Type I IFN receptor binding and activation.
  • Explanation of downstream signaling cascades (e.g., JAK-STAT pathway).
  • Identification of key transcription factors and effector genes induced by Type I IFNs.

Conclusions:

  • Type I IFNs initiate complex intracellular signaling cascades.
  • These pathways culminate in the expression of genes critical for antiviral defense and immune modulation.
  • Understanding these molecular events is key to harnessing IFN functions therapeutically.

Related Experiment Videos