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Related Experiment Videos

Major histocompatibility complex effect on cellulitis among different chicken lines.

K S Macklin1, S J Ewald, R A Norton

  • 1Department of Poultry Science, and Department of Pathobiology, Auburn University, Auburn, AL 36849-5416, USA.

Avian Pathology : Journal of the W.V.P.A
|October 25, 2002
PubMed
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Chicken major histocompatibility complex (MHC) B(21) alleles increase cellulitis susceptibility in both broiler and Leghorn lines. Conversely, B(13) alleles confer resistance, with heterozygous birds showing intermediate outcomes.

Area of Science:

  • Poultry genetics
  • Immunology
  • Disease resistance

Background:

  • The chicken major histocompatibility complex (MHC) influences disease resistance and susceptibility.
  • Specific MHC haplotypes, such as B(13) and B(21), have been linked to differential outcomes in Marek's disease and Escherichia coli infections.

Purpose of the Study:

  • To investigate the role of chicken MHC haplotypes B(13) and B(21) in susceptibility to Escherichia coli-induced cellulitis.
  • To compare cellulitis incidence and severity between broiler and Leghorn chicken lines with defined MHC types.

Main Methods:

  • Broiler and Leghorn chickens with homozygous B(13), homozygous B(21), or heterozygous B(13)/B(21) MHC types were challenged with an E. coli isolate.
  • Incidence of cellulitis development was recorded.

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  • Severity of cellulitis lesions was assessed.

    • Main Results:

    • Homozygous B(21) chickens exhibited the highest incidence of cellulitis development in both broiler and Leghorn lines.
    • Homozygous B(13) chickens showed the lowest incidence of cellulitis.
    • Cellulitis lesion severity was not significantly influenced by MHC type.

    Conclusions:

    • The B(21) MHC haplotype is associated with increased susceptibility to E. coli-induced cellulitis in chickens.
    • The B(13) MHC haplotype confers resistance to cellulitis.
    • MHC type significantly impacts cellulitis incidence but not lesion severity.