Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Three TNFalpha single nucleotide polymorphisms in the Japanese population.

Y Shinohara1, Y Ezura, H Iwasaki

  • 1Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan.

Annals of Human Biology
|October 25, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Supernumerary ring chromosomes and nuclear blebs in some low-grade malignant soft tissue tumours: atypical lipomatous tumours and dermatofibrosarcoma protuberans.

Virchows Archiv : an international journal of pathology·1998
Same author

Abortive recombination in Escherichia coli ruv mutants blocks chromosome partitioning.

Genes to cells : devoted to molecular & cellular mechanisms·1998
Same author

Reirradiation therapy for brain metastases from small cell lung cancer.

Radiation medicine·1998
Same author

Remission induction by granulocyte colony-stimulating factor in hypoplastic acute myelogenous leukemia complicated by infection. A case report and review of the literature.

Acta haematologica·1998
Same author

[The efficacy of low-dose propofol for intrathecal morphine-induced pruritus].

Masui. The Japanese journal of anesthesiology·1998
Same author

[Preventive effect of fluid warmer system on hypothermia induced by rapid intravenous infusion].

Masui. The Japanese journal of anesthesiology·1998
Same journal

A comparison of interpupillary distances between Turkish and Azerbaijani populations.

Annals of human biology·2026
Same journal

Association between CHRNA5 polymorphisms and Parkinson's disease in Northern Chinese Han population: a case-control study.

Annals of human biology·2026
Same journal

Nanopore sequencing technology in forensic science: status quo and tendency.

Annals of human biology·2026
Same journal

Body composition phenotyping of obesity in children aged 6-18 years: multi-strategy clustering and interpretable machine learning.

Annals of human biology·2026
Same journal

Associations between growth, maturation and non-contact injury risk in Scottish male academy football: a prospective multi-academy study.

Annals of human biology·2026
Same journal

Observation of the therapeutic effect of flunarizine capsules combined with the Epley manoeuvre in the treatment of benign paroxysmal positional vertigo.

Annals of human biology·2026
See all related articles

This study identified three single nucleotide polymorphisms (SNPs) in the Tumor Necrosis Factor-alpha (TNFalpha) gene in the Japanese population, with one novel SNP. Allele frequencies differed significantly from other populations, highlighting ethnic variations.

Area of Science:

  • Genetics
  • Immunology
  • Population Studies

Background:

  • Tumor Necrosis Factor-alpha (TNFalpha) regulates immune responses and is linked to disease susceptibility.
  • Understanding population-specific genetic variations is crucial for disease research.

Purpose of the Study:

  • To characterize single nucleotide polymorphisms (SNPs) within the TNFalpha gene in the Japanese population.
  • To establish accurate allele frequency data for TNFalpha SNPs in this demographic.

Main Methods:

  • Direct sequencing of the entire TNFalpha gene in 48 Japanese chromosomes (24 individuals).
  • Determination of allele frequencies for identified polymorphisms.
  • Comparison of findings with existing population data.

Related Experiment Videos

Main Results:

  • Three TNFalpha SNPs were identified: -308G/A, IVS1 + 125G/A, and a novel IVS3 + 104G/A.
  • Significant ethnic differences in allele frequencies were observed, particularly for the -308G/A SNP compared to NCBI dbSNP data.

Conclusions:

  • The identified TNFalpha polymorphisms and their frequencies provide valuable data for Japanese genetic studies.
  • This information can aid in the genetic investigation of common diseases like osteoporosis and rheumatoid arthritis in Japan.