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Related Experiment Videos

A novel method for preparation of Eudragit RL microcapsules.

P M Satturwar1, P M Mandaogade, A K Dorle

  • 1Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur-440 010 (MS), India. satturwar@yahoo.com

Journal of Microencapsulation
|October 25, 2002
PubMed
Summary

A new solvent evaporation method efficiently prepares Eudragit RL microcapsules for sustained drug release. Increasing polymer concentration enhanced drug release control, offering a convenient approach for Eudragit RL microcapsule formulation.

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Microencapsulation is crucial for controlled drug release.
  • Eudragit RL is a widely used polymer for pharmaceutical formulations.
  • Developing efficient and scalable microencapsulation techniques is essential.

Purpose of the Study:

  • To introduce a novel, rapid, and convenient method for preparing Eudragit RL microcapsules.
  • To encapsulate diclofenac sodium as a model drug.
  • To investigate the effect of polymer concentration on drug release kinetics.

Main Methods:

  • Employed a solvent evaporation technique.
  • Dissolved Eudragit RL and diclofenac sodium in an acetone-isopropyl alcohol mixture (1:1).

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  • Sprayed the drug-polymer solution into liquid paraffin to form microcapsules.

    • Main Results:

    • Successfully prepared uniform, free-flowing Eudragit RL microcapsules.
    • Demonstrated sustained release of diclofenac sodium from the microcapsules.
    • Observed that higher polymer concentrations led to more sustained drug release.

    Conclusions:

    • The described solvent evaporation method is a rapid and convenient approach for Eudragit RL microcapsule preparation.
    • The technique allows for tunable drug release profiles by adjusting polymer concentration.
    • This method holds promise for the development of advanced drug delivery systems.