Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolution and status of bone and marrow dose models.

M G Stabin1, K F Eckerman, W E Bolch

  • 1Department of Radiology and Radiological Sciences Vanderbilt University, Nashville, TN 37232, USA. michael.g.stabin@vanderbilt.edu

Cancer Biotherapy & Radiopharmaceuticals
|October 25, 2002
PubMed
Summary

This study refines marrow dose conversion factors (DCFs) for beta emitters in bone, comparing historical and updated models. New data improves accuracy for internal emitter therapy radiation dosimetry.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neutron dose coefficients for the lens of the eye.

Journal of radiological protection : official journal of the Society for Radiological Protection·2021
Same author

ICRP Publication 145: Adult Mesh-Type Reference Computational Phantoms.

Annals of the ICRP·2020
Same author

ICRP Publication 144: Dose Coefficients for External Exposures to Environmental Sources.

Annals of the ICRP·2020
Same author

ICRP Publication 143: Paediatric Reference Computational Phantoms.

Annals of the ICRP·2020
Same author

Neutron dose coefficients for local skin.

Journal of radiological protection : official journal of the Society for Radiological Protection·2020
Same author

ICRP Publication 140: Radiological Protection in Therapy with Radiopharmaceuticals.

Annals of the ICRP·2019

Area of Science:

  • Medical Physics
  • Radiological Dosimetry
  • Nuclear Medicine

Background:

  • Early work by Spiers established marrow dose conversion factors (DCFs) for beta-emitting radionuclides in bone.
  • Subsequent models by Eckerman and Bouchet et al. refined these calculations using updated data and 3D electron transport techniques.

Purpose of the Study:

  • To review and compare existing skeletal models for calculating radionuclide S values.
  • To address discrepancies in models concerning red marrow definition, surface activity sources, and electron transport through the endosteum.
  • To present a revised model incorporating new data from NMR microscopy and radiation transport.

Main Methods:

  • Review of chord-based skeletal models.
  • Analysis of differences between Eckerman and Bouchet et al. transport models.

Related Experiment Videos

  • Application of new NMR microscopy and trabecular bone radiation transport data.
  • Comparison of DCFs from MIRD 11, Eckerman, Bouchet et al., and a revised model.

    • Main Results:

    • Identified key differences in skeletal models, including red marrow definition and electron transport assumptions.
    • New data provides a basis for a revised model of radionuclide transport in trabecular bone.
    • Comparison highlights variations in DCFs across different models for key radionuclides.

    Conclusions:

    • The study provides a critical comparison of existing and revised models for marrow DCFs.
    • Updated data and refined models are crucial for accurate internal emitter therapy dosimetry.
    • Further research can enhance the precision of radiation dose calculations in skeletal tissues.