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Related Experiment Videos

Clustered schedules in allergen-specific immunotherapy.

S Parmiani1, L Fernández Távora, C Moreno

  • 1Alk-Abelló. Italy. silvano_parmiani@allergia.it

Allergologia Et Immunopathologia
|October 25, 2002
PubMed
Summary

Clustered schedules for injective immunotherapy may improve patient compliance and reduce costs compared to traditional build-up phases. Optimal tolerance is achieved with premedication, depot preparations, and limited administrations per cluster.

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Area of Science:

  • Allergy and Immunology
  • Pharmacology

Background:

  • Traditional injective immunotherapy involves a lengthy 3-4 month build-up phase.
  • This traditional schedule can lead to reduced patient and clinician compliance and increased inconvenience.
  • Alternative schedules may offer a more practical approach to immunotherapy.

Purpose of the Study:

  • To review published literature on clustered schedules for injective immunotherapy.
  • To assess the tolerance of clustered schedules and identify factors influencing side effects.
  • To provide recommendations for optimizing clustered immunotherapy schedules.

Main Methods:

  • A systematic revision of published papers focusing on clustered immunotherapy schedules.
  • Papers were categorized into two groups: those using clustered schedules incidentally and those specifically studying them.

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  • Analysis focused on tolerance and its relationship with extract type, allergen presentation, schedule parameters, premedication, and patient clinical manifestations.

    • Main Results:

    • Significant variability in side effect rates was observed across studies, even with similar allergens and schedules.
    • Factors influencing optimal tolerance included the use of premedication and depot preparations.
    • Specific parameters for clustered schedules included no more than 4 administrations per cluster, 1-2 clusters per week, and 4-6 clusters total.

    Conclusions:

    • Clustered schedules for injective immunotherapy show promise for improving tolerance.
    • Optimal tolerance appears linked to premedication, depot preparations, and specific administration frequencies and total cluster numbers.
    • Further research is needed to definitively establish the optimal clustered immunotherapy schedule.