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Comparison of MS-325- and gadodiamide-enhanced MR venography of iliocaval veins

Melhem J Sharafuddin1, Alan H Stolpen, Yvonne M Dang

  • 1Department of Radiology, University of Iowa College of Medicine, 3889 JPP, 200 Hawkins Drive, Iowa City, Iowa 52242, USA. mel-sharafuddin@uiowa.edu

Journal of Vascular and Interventional Radiology : JVIR
|October 25, 2002
PubMed
Abstract

Insights

MS-325 contrast agent significantly improved visualization of the iliocaval veins in indirect contrast-enhanced 3D MR venography compared to gadodiamide. This blood-pool agent offers superior diagnostic conspicuity for venous imaging.

Area of Science:

  • Radiology
  • Medical Imaging
  • Vascular Imaging

Background:

  • Indirect contrast-enhanced three-dimensional (3D) MR venography is a key technique for visualizing the iliocaval veins.
  • Conventional extracellular and blood-pool contrast agents have varying efficacies in this application.
  • Optimizing contrast agents is crucial for improving diagnostic accuracy in venous imaging.

Purpose of the Study:

  • To compare the diagnostic performance of extracellular (gadodiamide) and blood-pool (MS-325) contrast agents in indirect contrast-enhanced 3D MR venography of the iliocaval veins.

Main Methods:

  • Retrospective review of 29 gadodiamide-enhanced (Gd-MR) and 12 MS-325-enhanced (MS-325-MR) 3D MR angiography studies.
  • Studies were analyzed with and without subtraction by two blinded observers.
  • Subjective scoring of diagnostic conspicuity, contrast, and artifacts in suprarenal IVC, infrarenal IVC, and iliac veins.

Main Results:

  • MS-325-MR demonstrated significantly higher visualization rates (92%-100%) for infrarenal IVC and iliac veins compared to Gd-MR (55%).
  • Subtraction improved conspicuity and contrast in Gd-MR but increased artifacts and blurring.
  • Subtraction provided minimal diagnostic benefit in MS-325-MR studies.

Conclusions:

  • Indirect contrast-enhanced 3D MR venography using MS-325 provides superior diagnostic conspicuity and contrast for iliocaval venous opacification.
  • MS-325 is a more effective blood-pool contrast agent than gadodiamide for this specific venographic application.

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