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Renin secretion at the individual nephron level.

T Morgan, J M Davis

    Pflugers Archiv : European Journal of Physiology
    |August 29, 1975
    PubMed
    Summary
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    Renin concentration in the renal vein is higher than in the aorta, suggesting renin enters circulation at the capillary level. This supports intra-renal function of the renin-angiotensin system.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Physiology

    Background:

    • The renin-angiotensin system (RAS) plays a crucial role in regulating blood pressure and fluid balance.
    • Understanding the precise site and mechanism of renin secretion is vital for comprehending RAS regulation.

    Purpose of the Study:

    • To investigate the concentration gradient of renin in renal blood vessels.
    • To elucidate the pattern of renin secretion into the circulation.

    Main Methods:

    • Blood samples were collected from the descending aorta, renal efferent arteriole, and renal vein of rats.
    • Renin concentrations in these samples were quantified.

    Main Results:

    • Renal vein renin concentration (673 ng ml-1h-1) was significantly higher than aortic concentration (456 ng ml-1h-1).

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  • Renin concentration in the renal efferent arteriole was lower than in the aorta.
  • These findings suggest renin removal occurs between the artery and efferent arteriole, and entry occurs between the efferent arteriole and renal vein.

    • Conclusions:

    • Net renin secretion involves removal and entry processes, with renin likely released into the interstitium and entering circulation at the capillary level.
    • This secretion pattern supports the hypothesis that the RAS primarily functions intra-renally, rather than solely through the systemic circulation.