Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiovascular effects of androgens.

Wolfgang Weidemann1, Hartmut Hanke

  • 1Department of General Zoology and Endocrinology, University of Ulm, Albert-Einstein-Allee 11, 89069 Ulm, Germany. wolfgang.weidemann@biologie.uni-ulm.de.

Cardiovascular Drug Reviews
|October 25, 2002
PubMed
Summary

Androgens, like testosterone, have complex cardiovascular effects. While previously viewed negatively, recent research shows potential benefits for the arterial system, impacting lipid metabolism and plaque formation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AR-Q640X, a model to study the effects of constitutively active C-terminally truncated AR variants in prostate cancer cells.

World journal of urology·2012
Same author

Impact of aerobic exercise training on cognitive functions and affect associated to the COMT polymorphism in young adults.

Neurobiology of learning and memory·2010
Same author

Photoconvertible fluorescent protein EosFP: biophysical properties and cell biology applications.

Photochemistry and photobiology·2006
Same author

Septic shock caused by Streptococcus pneumoniae in a post-splenectomy patient successfully treated with recombinant human activated protein C.

Scandinavian journal of infectious diseases·2006
Same author

Intimal hyperplasia and expression of transforming growth factor-beta1 in saphenous veins and internal mammary arteries before coronary artery surgery.

The Annals of thoracic surgery·2004
Same author

Markers of inflammation in women on different hormone replacement therapies.

Annals of medicine·2003

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Vascular Biology

Background:

  • Sex steroids, including estrogens and androgens, play a complex role in atherosclerosis.
  • Estrogen replacement therapy's cardiovascular benefits are debated, with recent clinical trials failing to reduce mortality.
  • Androgen effects on the cardiovascular system are controversial, shifting from perceived adverse impacts to documented beneficial actions.

Purpose of the Study:

  • To review the multifaceted and sometimes contradictory effects of androgens on the cardiovascular system.
  • To explore the influence of androgens on lipid metabolism, hemostasis, and arterial wall physiology.
  • To discuss potential signal transduction pathways involved in androgen's cardiovascular actions.

Main Methods:

  • Review of experimental studies, clinical trials, animal research, and in vitro investigations.

Related Experiment Videos

  • Analysis of data on androgen effects on lipid profiles (LDL, HDL, Lp(a)) and hemostasis (platelet aggregation, fibrinolysis).
  • Examination of studies on androgenic impact on coronary vasomotion, ischemia, and neointimal plaque formation.

    • Main Results:

    • Estrogens show an atheroprotective effect in experimental models, but clinical benefits in reducing cardiovascular mortality are not confirmed.
    • Androgens demonstrate beneficial actions in the arterial vascular system, contrary to past beliefs.
    • Androgens influence key cardiovascular risk factors, including lipid metabolism and hemostasis, and inhibit neointimal plaque formation.

    Conclusions:

    • Androgens exert diverse and complex effects on the cardiovascular system, with emerging evidence of beneficial actions.
    • Understanding androgen signaling pathways is crucial for elucidating their role in cardiovascular health and disease.
    • Further research is needed to reconcile contradictory findings and fully understand androgen's cardiovascular impact.