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Related Experiment Videos

Expression patterns of neurotrophic factor mRNAs in developing human teeth.

Irina Nosrat1, Ake Seiger, Lars Olson

  • 1Laboratory of Oral Neurobiology, University of Michigan Dental School, Ann Arbor, MI 48109-1078, USA. inosrat@umich.edu

Cell and Tissue Research
|October 25, 2002
PubMed
Summary

Neurotrophic factors like NGF and BDNF are expressed in developing human teeth, suggesting roles in tooth morphogenesis and innervation. These factors may also offer therapeutic potential for nervous system disorders.

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Area of Science:

  • Developmental Biology
  • Neuroscience
  • Oral Biology

Background:

  • Neurotrophic factors regulate neural development and plasticity.
  • Rodent studies suggest neurotrophic factors are involved in tooth development.
  • Human relevance of these findings remains to be established.

Purpose of the Study:

  • To investigate the mRNA expression patterns of key neurotrophic factors and GDNF in early developing human teeth.
  • To determine the potential roles of these factors in human tooth morphogenesis and innervation.

Main Methods:

  • Studied mRNA expression of NGF, BDNF, NT-3, NT-4, GDNF, and NTN in human teeth (gestational weeks 6.5-11).
  • Utilized in situ hybridization histochemistry for precise localization of gene expression.
  • Observed PGP 9.5-immunoreactive nerve fibers to assess innervation.

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Main Results:

  • Distinct spatial and temporal mRNA expression patterns were observed for NGF, BDNF, NT-3, NT-4, GDNF, and NTN in developing human dental tissues.
  • Specific neurotrophic factors were localized to the dental papilla, mesenchyme, and various epithelial structures.
  • Nerve fibers were detected in the dental follicle by 11 weeks, coinciding with neurotrophic factor mRNA expression.

Conclusions:

  • Neurotrophins, GDNF, and NTN are likely involved in morphogenetic events during early human tooth development.
  • These factors may play a role in the innervation of developing dental structures.
  • Developing human dental tissues represent a potential source for allografts providing trophic support for nervous system diseases.