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The IUPS human Physiome Project.

Peter Hunter1, Peter Robbins, Denis Noble

  • 1Bioengineering Institute, University of Auckland, New Zealand. p.hunter@auckland.ac.nz

Pflugers Archiv : European Journal of Physiology
|October 25, 2002
PubMed
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The Physiome Project uses computational modeling to create a comprehensive human body framework. This initiative integrates biochemistry, biophysics, and anatomy for analyzing biological functions across scales.

Area of Science:

  • Physiological modeling
  • Computational biology
  • Systems biology

Background:

  • The International Union of Physiological Sciences (IUPS) initiated the Physiome Project.
  • Aims to develop a comprehensive computational framework for the human body.
  • Integrates biochemistry, biophysics, and anatomy across cellular, tissue, and organ levels.

Purpose of the Study:

  • To analyze integrative biological function using computational modeling.
  • To understand biological functions in terms of underlying structure and molecular mechanisms.
  • To establish web-accessible physiological databases for model-related data.

Main Methods:

  • Developing computational models of human physiology.
  • Addressing challenges in multi-scale spatial and temporal modeling.

Related Experiment Videos

  • Creating model ontologies and markup languages for biological functions.

    • Main Results:

    • Establishing web-accessible physiological databases.
    • Discussing the background, goals, and challenges of the Physiome Project.
    • Outlining the development of ontologies and markup languages for physiological modeling.

    Conclusions:

    • The Physiome Project is developing a unified framework for human body modeling.
    • Computational modeling and integrated databases are crucial for understanding complex biological systems.
    • Standardized ontologies and markup languages are essential for multi-scale physiological research.