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Platelet adhesiveness and cancer cell stickiness: a comparative study
Pflugers Archiv : European Journal of Physiology
|December 19, 1975
Summary
Platelet adhesiveness differs significantly from cancer cell stickiness. Platelets aggregate rapidly and are influenced by electric currents, while cancer cells adhere continuously and passively, especially at low flow velocities.
Area of Science:
- Biophysics
- Cell Biology
- Oncology
Background:
- Platelets play a crucial role in hemostasis and thrombosis.
- Cancer cell adhesion is a critical step in metastasis.
Purpose of the Study:
- To compare the adhesive properties of platelets and Yoshida sarcoma cells.
- To investigate the influence of flow velocity and electric currents on cell adhesion.
Main Methods:
- Utilized the Fibre test to assess platelet adhesiveness and cancer cell stickiness.
- Measured cell accumulation and adhesion under varying flow velocities.
- Applied an experimentally induced streaming electric current to evaluate its effect on adhesion.
Main Results:
- Platelets exhibited rapid aggregation within seconds, while Yoshida sarcoma cells showed continuous accumulation.
- Platelet adhesiveness peaked at 7 cm/sec flow velocity; cancer cells adhered better at lower velocities.
- An electric current (40 mV) doubled platelet adhesiveness but did not affect cancer cell adhesion.
Conclusions:
- Platelet adhesion involves active interaction with the vessel wall.
- Yoshida sarcoma cell adhesion appears to be a passive process.
- Differences in adhesion mechanisms may have implications for understanding cancer metastasis and thrombosis.