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[Cardiac resynchronization therapy by biventricular pacing. How many patients with left ventricular dysfunction are
1Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Germany. alex.yang@web.de
Deutsche Medizinische Wochenschrift (1946)
|October 25, 2002
Summary
Multisite biventricular pacing offers a therapeutic option for severe heart failure patients with left ventricular dysfunction. This study identified a small but significant subgroup potentially benefiting from this advanced cardiac resynchronization therapy.
Area of Science:
- Cardiology
- Electrophysiology
- Heart Failure Management
Background:
- Severe congestive heart failure impacts many patients.
- Left ventricular dysfunction is a key characteristic.
- Multisite biventricular pacing is an emerging therapy.
Purpose of the Study:
- To determine the prevalence of patients with left ventricular dysfunction.
- To identify the proportion of these patients who could benefit from biventricular pacing.
Main Methods:
- Screened 975 patients for left ventricular dysfunction (LVEF <45%).
- Included patients with LVEF <35%, NYHA class III/IV heart failure, QRS >150ms, and no recent atrial fibrillation.
- Assessed eligibility for biventricular resynchronization therapy.
Main Results:
- 203 patients had LVEF <45%.
- 12 patients (6% of those with LVEF <45%, 11% of those with LVEF <35%) met criteria for biventricular pacing.
- Identified specific criteria for potential benefit.
Conclusions:
- Cardiac biventricular pacing benefits a select group of patients with left ventricular dysfunction.
- Over 6,000 patients in Germany may benefit annually.
- Further research could expand eligibility to patients with atrial fibrillation or conduction delays.