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[Tendency and prospect of the development of new ARBs]

Shokei Kim1

  • 1Department of Pharmacology, Osaka City University Medical School.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|October 26, 2002
PubMed

Insights

Angiotensin II receptor blockers (ARBs) offer distinct advantages over ACE inhibitors for cardiovascular diseases. This review details current and emerging ARBs, highlighting their pharmacological properties and future clinical applications.

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Nephrology

Context:

  • Angiotensin II receptor blockers (ARBs) present unique pharmacological advantages compared to ACE inhibitors.
  • Current clinical use in Japan includes losartan potassium, candesartan cilexetil, and valsartan.
  • Several novel ARBs, such as telmisartan, ormethartan, and irbesartan, are anticipated for future clinical availability.

Purpose:

  • To review the pharmacological properties of existing and emerging Angiotensin II receptor blockers (ARBs).
  • To discuss the future clinical perspectives and applications of various ARBs in cardiovascular and renal diseases.

Summary:

  • This review examines the distinct pharmacological merits of Angiotensin II receptor blockers (ARBs) in comparison to ACE inhibitors.
  • It details the properties of currently used ARBs in Japan (losartan potassium, candesartan cilexetil, valsartan) and upcoming agents (telmisartan, ormethartan, irbesartan).
  • The discussion encompasses the pharmacological profiles and future outlook for each ARB.

Impact:

  • Provides a comprehensive overview of ARBs for treating hypertension, heart failure, and nephropathy.
  • Informs clinicians and researchers about the therapeutic potential and comparative advantages of different ARBs.
  • Facilitates understanding of the evolving landscape of cardiovascular and renal disease pharmacotherapy.

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