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Different distribution of Dukes' stage between proximal and distal colorectal cancer
Yoichi Ikeda1, Kazunari Akagi, Junko Kinoshita
1Department of Surgery II, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Background/Aims:
As different features of colorectal cancer between proximal and distal sites are influenced mainly by proximal shift and diagnostic improvement, a comparison of proximal and distal cancer sites may provide clues as to appropriate strategy for colorectal cancer treatment.
Methodology:
The clinicopathological data on 676 patients with colorectal cancer was compared regarding the proximal and distal sites.
Results:
In cases of cancer without metastasis (Dukes' A or B), the incidence of Dukes' A was higher in the distal than in the proximal site (11.2% vs. 24.3%), while the incidence of Dukes' B was lower in the distal than the proximal site. In cases of cancer with metastasis (Dukes' C or D), the incidence of Dukes' C and Dukes' D tumors was similar between proximal and distal sites.
Conclusions:
A large number of Dukes' A cancer in distal site may be slow growing with low metastatic potential.
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